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Journal article

Loss of the BMP antagonist USAG-1 ameliorates disease in a mouse model of the progressive hereditary kidney disease Alport syndrome.

Abstract:

The glomerular basement membrane (GBM) is a key component of the filtering unit in the kidney. Mutations involving any of the collagen IV genes (COL4A3, COL4A4, and COL4A5) affect GBM assembly and cause Alport syndrome, a progressive hereditary kidney disease with no definitive therapy. Previously, we have demonstrated that the bone morphogenetic protein (BMP) antagonist uterine sensitization-associated gene-1 (USAG-1) negatively regulates the renoprotective action of BMP-7 in a mouse model o...

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Publication status:
Published

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Publisher copy:
10.1172/jci39569

Authors


Higashi, AY More by this author
Nakamura, J More by this author
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Journal:
The Journal of clinical investigation
Volume:
120
Issue:
3
Pages:
768-777
Publication date:
2010-03-05
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
URN:
uuid:48fe44d4-5285-49e6-96f0-9dd62b112436
Source identifiers:
245639
Local pid:
pubs:245639

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