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Altered plasma versus vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial function, and inflammation.

Abstract:

BACKGROUND: Tetrahydrobiopterin (BH4) is a key regulator of endothelial nitric oxide synthase (eNOS) activity and coupling. However, the extent to which vascular and/or systemic BH4 levels are altered in human atherosclerosis and the importance of BH4 bioavailability in determining endothelial function and oxidative stress remain unclear. We sought to define the relationships between plasma and vascular biopterin levels in patients with coronary artery disease and to determine how BH4 levels ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine
Role:
Author
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Journal:
Circulation
Volume:
116
Issue:
24
Pages:
2851-2859
Publication date:
2007-12-05
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
URN:
uuid:48ef8051-f1f8-4a4f-8500-00628956f2b4
Source identifiers:
104862
Local pid:
pubs:104862

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