Duration of TCR stimulation determines costimulatory requirement of T cells.

Journal article

Current models suggest that T cells that receive only signal-1 through antigenic stimulation of the T cell receptor (TCR) become anergic, but will mount an immune response when a costimulatory signal-2 is provided. Using mice deficient for an important costimulatory molecule, CD28, we show that a transient signal-1 alone, either through infection with an abortively replicating virus, or through injection of viral peptide, anergizes CD8+ T cells, demonstrating the biological relevance of T cell anergy in vivo. However, in the absence of CD28, continued presence of signal-1 alone, either through prolonged viral replication or repeated injection of peptide, prevents the induction of anergy and generates a functional T cell response in vivo.

Authors: Kündig, T; Shahinian, A; Kawai, K; Mittrücker, H; Sebzda, E

• Publication status: Published
• Journal: Immunity
• Volume: 5
• Issue: 1
• Pages: 41-52
• Publication date: 1996-07-01
• DOI: 10.1016/s1074-7613(00)80308-8
• EISSN: 1097-4180
• ISSN: 1074-7613
• Language: English
• Keywords: Virus Replication; Animals; Clonal Deletion; Mice, Mutant Strains; Antigens, Viral; Mice; Antigens, CD28; Cytotoxicity, Immunologic; Mice, Inbred C57BL; Lymphocytic choriomeningitis virus; Immune Tolerance; Mice, Inbred CBA; Dose-Response Relationship, Immunologic; Receptors, Antigen, T-Cell; T-Lymphocytes, Cytotoxic; Lymphocyte Activation