Journal article
Long non-coding RNA-derived peptides are immunogenic and drive a potent anti-tumour response
- Abstract:
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Protein arginine methyltransferase (PRMT) 5 is over-expressed in a variety of cancers and the master transcription regulator E2F1 is an important methylation target. We have explored the role of PRMT5 and E2F1 in regulating the non-coding genome and report here a striking effect on long non-coding (lnc) RNA gene expression. Moreover, many MHC class I protein-associated peptides were derived from small open reading frames in the lncRNA genes. Pharmacological inhibition of PRMT5 or adjusting E2...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 3.0MB, Terms of use)
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- Publisher copy:
- 10.1038/s41467-023-36826-0
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Funding
Bibliographic Details
- Publisher:
- Springer Nature
- Journal:
- Nature Communications More from this journal
- Volume:
- 14
- Issue:
- 1
- Article number:
- 1078
- Place of publication:
- England
- Publication date:
- 2023-02-25
- Acceptance date:
- 2023-02-15
- DOI:
- EISSN:
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2041-1723
- Pmid:
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36841868
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1330609
- Local pid:
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pubs:1330609
- Deposit date:
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2023-10-17
Terms of use
- Copyright holder:
- Barczak et al
- Copyright date:
- 2023
- Rights statement:
- © 2023 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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