Musculoskeletal health state and physical function of intensive care unit survivors: protocol for a UK multicentre prospective cohort study (the MSK-ICU study)

Gustafson, O; King, E; Schlussel, M; Rowland, M; Dawes, H; Williams, MA

Journal article

Musculoskeletal health state and physical function of intensive care unit survivors: protocol for a UK multicentre prospective cohort study (the MSK-ICU study)

Abstract:: IntroductionSurvivors of critical illness frequently experience long-term physical impairment, decreased health-related quality of life and low rates of return to employment. There has been limited investigation of the underlying problems affecting physical function post-intensive care unit (ICU) admission. Musculoskeletal (MSK) conditions may be complex in presentation, with ICU survivors potentially at greater risk of their development due to the rapid muscle mass loss seen in ICU. The MSK health state of ICU survivors and its impact on physical function remain largely unknown. The aim of the MSK-ICU study is to determine and characterise the MSK health state of ICU survivors 6 months following admission to ICU, in order to inform development of targeted rehabilitation interventions.Methods and analysisThe MSK-ICU study is a multicentre prospective longitudinal cohort study, evaluating the MSK health state of ICU survivors 6 months after admission to ICU. The study consists of a primary study and two substudies. The primary study will be a telephone follow-up of adults admitted to ICU for more than 48 hours, collecting data on MSK health state, quality of life, employment, anxiety and depression and symptoms of post-traumatic stress disorder. The planned sample size is 334 participants. Multivariable regression will be used to identify prognostic factors for a worse MSK health state, as measured by the MSK-Health Questionnaire. In substudy 1, participants who self-report any MSK problem will undergo a detailed, in-person MSK physical assessment of pain, peripheral joint range of movement and strength. In substudy 2, participants reporting a severe MSK problem will undergo a detailed physical assessment of mobility, function and muscle architecture.Ethics and disseminationEthical approval has been obtained through the North of Scotland Research Ethics Committee 2 (21/NS/0143). We aim to disseminate the findings through international conferences, international peer-reviewed journals and social media.Trial registration numberISRCTN24998809.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Gustafson, O., King, E., Schlussel, M., Rowland, M., Dawes, H., & Williams, M. A. (2023). Musculoskeletal health state and physical function of intensive care unit survivors: protocol for a UK multicentre prospective cohort study (the MSK-ICU study). BMJ Open, 13(2), e071385–e071385.

MLA Style

Gustafson, O, et al. “Musculoskeletal Health State and Physical Function of Intensive Care Unit Survivors: Protocol for a UK Multicentre Prospective Cohort Study (the MSK-ICU Study).” BMJ Open, vol. 13, no. 2, 2023, pp. e071385–e071385.

Chicago Style

Gustafson, O, E King, M Schlussel, M Rowland, H Dawes, and MA Williams. 2023. “Musculoskeletal Health State and Physical Function of Intensive Care Unit Survivors: Protocol for a UK Multicentre Prospective Cohort Study (the MSK-ICU Study).” BMJ Open 13 (2): e071385–e071385.
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