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Structural and functional analysis of the putative pH sensor in the Kir1.1 (ROMK) potassium channel.

Abstract:

The pH-sensitive renal potassium channel Kir1.1 is important for K+ homeostasis. Disruption of the pH-sensing mechanism causes type II Bartter syndrome. The pH sensor is thought to be an anomalously titrated lysine residue (K80) that interacts with two arginine residues as part of an 'RKR triad'. We show that a Kir1.1 orthologue from Fugu rubripes lacks this lysine and yet is still highly pH sensitive, indicating that K80 is not the H+ sensor. Instead, K80 functionally interacts with A177 on ...

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Publication status:
Published

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Publisher copy:
10.1038/sj.embor.7400678

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Institution:
University of Oxford
Department:
Oxford, MPLS, Physics
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Journal:
EMBO reports
Volume:
7
Issue:
6
Pages:
611-616
Publication date:
2006-06-05
DOI:
EISSN:
1469-3178
ISSN:
1469-221X
URN:
uuid:48a7d68a-68ad-475c-aafb-b6ac3f4a6be4
Source identifiers:
28827
Local pid:
pubs:28827

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