The pH-sensitive renal potassium channel Kir1.1 is important for K+ homeostasis. Disruption of the pH-sensing mechanism causes type II Bartter syndrome. The pH sensor is thought to be an anomalously titrated lysine residue (K80) that interacts with two arginine residues as part of an 'RKR triad'. We show that a Kir1.1 orthologue from Fugu rubripes lacks this lysine and yet is still highly pH sensitive, indicating that K80 is not the H+ sensor. Instead, K80 functionally interacts with A177 on ...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
Structural and functional analysis of the putative pH sensor in the Kir1.1 (ROMK) potassium channel.
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record