Journal article : Letter
Normalising comparative effectiveness trials as clinical practice
- Abstract:
- There is a lack of high-quality evidence underpinning many contemporary clinical practice guidelines embedded in the healthcare systems, leading to treatment uncertainty and practice variation in most medical disciplines. Comparative effectiveness trials (CETs) represent a diverse range of research that focuses on optimising health outcomes by comparing currently approved interventions to generate high-quality evidence to inform decision makers. Yet, despite their ability to produce real-world evidence that addresses the key priorities of patients and health systems, many implementation challenges exist within the healthcare environment.This manuscript aims to highlight common barriers to conducting CETs and describes potential solutions to normalise their conduct as part of a learning healthcare system.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 701.5KB, Terms of use)
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- Publisher copy:
- 10.1186/s13063-021-05566-1
Authors
- Publisher:
- BioMed Central
- Journal:
- Trials More from this journal
- Volume:
- 22
- Article number:
- 620
- Publication date:
- 2021-09-15
- Acceptance date:
- 2021-08-24
- DOI:
- EISSN:
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1745-6215
- Pmid:
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34526083
- Language:
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English
- Keywords:
- Subtype:
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Letter
- Pubs id:
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1238948
- Local pid:
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pubs:1238948
- Deposit date:
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2022-02-11
Terms of use
- Copyright holder:
- Briffa et al.
- Copyright date:
- 2021
- Rights statement:
- ©2021 The Author(s). Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
- Licence:
- CC Attribution (CC BY)
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