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Pilot study to evaluate the need and implementation of a multifaceted nurse-led antimicrobial stewardship intervention in residential aged care

Abstract:
Objectives
To evaluate the need and feasibility of a nurse-led antimicrobial stewardship (AMS) programme in two Australian residential aged care homes (RACHs) to inform a stepped-wedged, cluster randomized controlled trial (SW-cRCT).

Methods
A mixed-methods pilot study of a nurse-led AMS programme was performed in two RACHs in Victoria, Australia (July-December 2019). The AMS programme comprised education, infection assessment and management guidelines, and documentation to support appropriate antimicrobial use in urinary, lower respiratory and skin/soft tissue infections. The programme was implemented over three phases: (i) pre-implementation education and integration (1 month); (ii) implementation of the intervention (3 months); and (iii) post-intervention evaluation (1 month). Baseline RACH and resident data and weekly infection and antimicrobial usage were collected and analysed descriptively to evaluate the need for AMS strategies. Feedback on intervention resources and implementation barriers were identified from semi-structured interviews, an online staff questionnaire and researcher field notes.

Results
Six key barriers to implementation of the intervention were identified and used to refine the intervention: aged care staffing and capacity; access to education; resistance to practice change; role of staff in AMS; leadership and ownership of the intervention at the RACH and organization level; and family expectations. A total of 61 antimicrobials were prescribed for 40 residents over the 3 month intervention. Overall, 48% of antibiotics did not meet minimum criteria for appropriate initiation (respiratory: 73%; urinary: 54%; skin/soft tissue: 0%).

Conclusions
Several barriers and opportunities to improve implementation of AMS in RACHs were identified. Findings were used to inform a revised intervention to be evaluated in a larger SW-cRCT.
Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1093/jacamr/dlae016

Authors

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
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Role:
Author
ORCID:
0000-0003-2031-9134


More from this funder
Funder identifier:
https://ror.org/0314h5y94
Grant:
GNT1152342
Programme:
Medical Research Future Fund


Publisher:
Oxford University Press
Journal:
JAC-Antimicrobial Resistance More from this journal
Volume:
6
Issue:
1
Article number:
dlae016
Place of publication:
England
Publication date:
2024-02-14
Acceptance date:
2024-01-12
DOI:
EISSN:
2632-1823
Pmid:
38371999


Language:
English
Pubs id:
2091669
Local pid:
pubs:2091669
Deposit date:
2025-06-12
ARK identifier:

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