The cardiovascular toxicity of antimalarial drugs

Thesis

Malaria is an ancient mosquito-borne parasitic disease from which over a thousand – mostly children in sub-Saharan Africa – still die of needlessly every day. For half a millennium, quinine and quinine-like antimalarial drugs have been the mainstay of malaria treatment and prevention. In the 18th century, the chance observation of their ability to quell palpitations led to their becoming the first anti-arrhythmic agents. Some of these anti-arrhythmic antimalarials later came to define the ...

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Authors: Chan, XHS

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: Severe malaria; Seasonal malaria chemoprevention; Uncomplicated malaria; Artemisinin-based combination therapy; Vivax; Falciparum; Mass drug administration; Case management; 4-aminoquinolines; Intermittent preventive treatment
• Subjects: Chloroquine; Long QT syndrome; Malaria; Arrhythmia; Hypotension; Malaria--Chemotherapy; Cardiac arrest; Mefloquine; Primaquine; Quinidine; Antimalarials; Quinine; Quinoline; Malaria--Prevention; Sudden death