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Journal article

Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns.

Abstract:

Researchers working on the development of vaccines face an inherent dilemma: to maximize immunogenicity without compromising safety and tolerability. Early vaccines often induced long-lived protective immune responses, but tolerability was a major problem. Newer vaccines have very few side effects but can be of limited immunogenicity. One way to tackle this problem is to design vaccines that have all the properties of pathogens with the exception of causing disease. Key features of pathogens ...

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Publication status:
Published

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Publisher copy:
10.1038/nri2868

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Jennings, GT More by this author
Journal:
Nature reviews. Immunology
Volume:
10
Issue:
11
Pages:
787-796
Publication date:
2010-11-05
DOI:
EISSN:
1474-1741
ISSN:
1474-1733
URN:
uuid:4771929b-8553-44fb-bcfa-b5cd2daec940
Source identifiers:
422325
Local pid:
pubs:422325
Language:
English
Keywords:

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