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Haploinsufficiency of AML1 affects the temporal and spatial generation of hematopoietic stem cells in the mouse embryo.

Abstract:

The AML1:CBFbeta transcription factor complex is essential for definitive hematopoiesis. Null mutations in mouse AML1 result in midgestational lethality with a complete lack of fetal liver hematopoiesis. While the cell autonomous nature and expression pattern of AML1 suggest an intrinsic role for this transcription factor in the developing hematopoietic system, no direct link to a functional cell type has been made. Here, we examine the consequences of AML1 loss in hematopoietic stem cells (H...

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Dortland, B More by this author
Luteijn, T More by this author
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Journal:
Immunity
Volume:
13
Issue:
4
Pages:
423-431
Publication date:
2000-10-05
DOI:
EISSN:
1097-4180
ISSN:
1074-7613
URN:
uuid:476cf262-8543-4938-a952-2e581cd6ac2a
Source identifiers:
263304
Local pid:
pubs:263304

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