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Allelic diversity and naturally acquired allele-specific antibody responses to Plasmodium falciparum apical membrane antigen 1 in Kenya.

Abstract:

Although Plasmodium falciparum apical membrane antigen 1 (AMA1) is a leading malaria vaccine candidate, extensive allelic diversity may compromise its vaccine potential. We have previously shown that naturally acquired antibodies to AMA1 were associated with protection from clinical malaria in this Kenyan population. To assess the impact of allelic diversity on naturally acquired immunity, we first sequenced the ectodomain-encoding region of P. falciparum ama1 from subjects with asymptomatic,...

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Publication status:
Published

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Publisher copy:
10.1128/iai.00576-10

Authors


Weedall, GD More by this author
Murungi, L More by this author
Tetteh, KK More by this author
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Journal:
Infection and immunity
Volume:
78
Issue:
11
Pages:
4625-4633
Publication date:
2010-11-05
DOI:
EISSN:
1098-5522
ISSN:
0019-9567
URN:
uuid:4742537f-f418-43d6-87ce-7aa58a3603a7
Source identifiers:
81585
Local pid:
pubs:81585

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