Journal article : Review
Characterising biomolecular interactions and dynamics with mass photometry
- Abstract:
- We review recent advances in our ability to characterise biomolecular structure, interactions and associated dynamics by mass photometry (MP), the label-free detection and mass measurement of individual biomolecules in solution. Molecular counting and identification provides direct access to relative abundance, and thereby affinities, while associated dynamics yield on- and off-rates. The molecular resolution afforded by MP enables these measurements as a function of stoichiometry and assembly at equilibrium, as opposed to the majority of existing solution-based methods. Together with future improvements in terms of assays and technological performance, MP is likely to provide mechanistic details of complex biomolecular processes.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.1MB, Terms of use)
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- Publisher copy:
- 10.1016/j.cbpa.2022.102132
Authors
- Publisher:
- Elsevier
- Journal:
- Current Opinion in Chemical Biology More from this journal
- Volume:
- 68
- Article number:
- 102132
- Publication date:
- 2022-04-08
- Acceptance date:
- 2022-02-22
- DOI:
- ISSN:
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1367-5931
- Language:
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English
- Keywords:
- Subtype:
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Review
- Pubs id:
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1250796
- Local pid:
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pubs:1250796
- Deposit date:
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2022-05-04
Terms of use
- Copyright holder:
- Asor and Kukura
- Copyright date:
- 2022
- Rights statement:
- © 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4.0/)
- Licence:
- CC Attribution (CC BY)
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