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Journal article

Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: A randomised, placebo-controlled phase 2b trial

Abstract:

Background BCG vaccination provides incomplete protection against tuberculosis in infants. A new vaccine, modified Vaccinia Ankara virus expressing antigen 85A (MVA85A), was designed to enhance the protective efficacy of BCG. We aimed to assess safety, immunogenicity, and efficacy of MVA85A against tuberculosis and Mycobacterium tuberculosis infection in infants. Methods In our double-blind, randomised, placebo-controlled phase 2b trial, we enrolled healthy infants (aged 4-6 months) without H...

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Publisher copy:
10.1016/S0140-6736(13)60177-4

Authors


Journal:
Lancet More from this journal
Volume:
381
Issue:
9871
Pages:
1021-1028
Publication date:
2013-03-01
DOI:
EISSN:
1474-547X
ISSN:
0140-6736


Pubs id:
pubs:395232
UUID:
uuid:4715d8d0-0d5f-4a0b-a845-caed92b75086
Local pid:
pubs:395232
Source identifiers:
395232
Deposit date:
2013-11-16
ARK identifier:

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