Journal article
Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: A randomised, placebo-controlled phase 2b trial
- Abstract:
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Background BCG vaccination provides incomplete protection against tuberculosis in infants. A new vaccine, modified Vaccinia Ankara virus expressing antigen 85A (MVA85A), was designed to enhance the protective efficacy of BCG. We aimed to assess safety, immunogenicity, and efficacy of MVA85A against tuberculosis and Mycobacterium tuberculosis infection in infants. Methods In our double-blind, randomised, placebo-controlled phase 2b trial, we enrolled healthy infants (aged 4-6 months) without H...
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- Publisher copy:
- 10.1016/S0140-6736(13)60177-4
Authors
- Journal:
- Lancet More from this journal
- Volume:
- 381
- Issue:
- 9871
- Pages:
- 1021-1028
- Publication date:
- 2013-03-01
- DOI:
- EISSN:
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1474-547X
- ISSN:
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0140-6736
- Pubs id:
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pubs:395232
- UUID:
-
uuid:4715d8d0-0d5f-4a0b-a845-caed92b75086
- Local pid:
-
pubs:395232
- Source identifiers:
-
395232
- Deposit date:
-
2013-11-16
- ARK identifier:
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- Copyright date:
- 2013
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