Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Journal article

Background: Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients. This study evaluated whether frequently assessed clinical outcomes via MyaLink can capture symptom variability between clinical visits. Methods: In this randomized, controlled, 12‐week study, 45 MG patients received either standard care (control, N = 15) or standard care with additional telemedical treatment (intervention, N = 30) including assessment of patient‐reported outcome measures, sensor‐based data, and patient‐physician messaging via a mobile application. Physicians performed telemedical check‐ups (TCUs) via a web‐based platform, adjusting treatment as needed. Results: In the intervention group, variability in clinical scores and sensor‐derived data was observed, particularly among those who experienced MG‐related hospitalizations or exacerbations (H&E subgroup). This subgroup showed larger MG‐ADL score fluctuations (mean range: 5.8 vs. 2.6 points), sent more messages, had more steroid dose adjustments (40% vs. 0%), and more frequent TCU interventions (93.3% vs. 60%) than the Non‐H&E subgroup. Interpretation: Telemedical platforms in MG might detect early signs of worsening. High‐risk patients (H&E subgroup) require increased medical support, which can be effectively addressed through MyaLink. Trial Registration: The study was registered under the German clinical trial registry (DRKS00029907)

Authors: Stein, M; Mönch, M; Herdick, M; Stascheit, F; Hoffmann, S

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Wiley
• Journal: Annals of Clinical and Translational Neurology
• Publication date: 2025-12-21
• Acceptance date: 2025-12-04
• DOI: 10.1002/acn3.70293
• EISSN: 2328-9503
• ISSN: 2328-9503
• Language: English
• Keywords: monitoring; telemedicine; remote consultation; myasthenia gravis; disease progression