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Characteristics of Plasmodium falciparum dhfr haplotypes that confer pyrimethamine resistance, Kilifi, Kenya, 1987--2006.

Abstract:

Resistance to the antimalarial drug sulfadoxine-pyrimethamine (SP) emerged in Plasmodium falciparum from Asia in the 1960s and subsequently spread to Africa. It is not known whether alleles that confer SP resistance also arose independently in Africa. We defined the coding region and microsatellite haplotypes of dhfr alleles in P. falciparum collected in Kilifi, Kenya, during 1987--2006, which spans the period when SP was first introduced. Isolates that carried a double-mutant or triple-mutan...

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Publication status:
Published

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Publisher copy:
10.1086/588198

Authors


Certain, LK More by this author
Briceño, M More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Watkins, WM More by this author
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Journal:
The Journal of infectious diseases
Volume:
197
Issue:
12
Pages:
1743-1751
Publication date:
2008-06-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:46d94f9d-2aeb-4b24-9d18-8fd97647062e
Source identifiers:
34252
Local pid:
pubs:34252

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