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Journal article

Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores.

Abstract:

Engineered protein pores have several potential applications in biotechnology: as sensor elements in stochastic detection and ultrarapid DNA sequencing, as nanoreactors to observe single-molecule chemistry, and in the construction of nano- and micro-devices. One important class of pores contains molecular adapters, which provide internal binding sites for small molecules. Mutants of the alpha-hemolysin (alphaHL) pore that bind the adapter beta-cyclodextrin (betaCD) approximately 10(4) times m...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0914229107

Authors


Banerjee, A More by this author
Mikhailova, E More by this author
Montoya, M More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
107
Issue:
18
Pages:
8165-8170
Publication date:
2010-05-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:46ca7138-6115-43dc-8fd5-242cb9d9ab36
Source identifiers:
53315
Local pid:
pubs:53315

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