Journal article
The impact of HIV-1 subtypes on virologic and immunologic treatment outcomes at the Lagos University Teaching Hospital: A longitudinal evaluation
- Abstract:
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Introduction
HIV is a highly diverse virus with significant genetic variability which may confer biologic differences that could impact on treatment outcomes.
Materials and methods
We studied the association between HIV subtypes and immunologic and virologic outcomes in a longitudinal cohort of 169 patients on combination antiretroviral therapy. Participants were followed up for 5 years. Demographic data, CD4 cell count and viral loads (VL) were extracted from medical records. Whole protease gene and codon 1–300 of the reverse transcriptase gene were sequenced and analysed.
Results
Sixty-four percent of participants were females with a median age of 35 years. Twelve different subtypes were observed, the commonest being CRF 02_AG (55.0%) and subtypes G (23.1%). All subtypes showed steady rise in CD4 count and there was no difference in proportion who achieved CD4+ cell count rise of ≥100 cells/μL from baseline within 12 months’ post-initiation of ART, or ≥350 cells/μL at 60 months’ post-initiation. Median time to attaining a rise of ≥350 cells/μL was 24 months (6–48 months). The proportion that achieved undetectable VL at month 6 and 12 post-initiation of ART were comparable across subtypes. At end of 5th year, there was no statistical difference in proportion with virologic failure.
Conclusion
No association between HIV subtypes and immunologic or virologic response to therapy was observed, suggesting that current first-line ART may have similar efficacy across subtype predominating in South-West Nigeria.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 820.6KB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pone.0238027
Authors
- Publisher:
- Public Library of Science
- Journal:
- PloS One More from this journal
- Volume:
- 15
- Issue:
- 8
- Article number:
- e0238027
- Publication date:
- 2019-08-25
- Acceptance date:
- 2020-08-10
- DOI:
- EISSN:
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1932-6203
- Pmid:
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32841264
- Language:
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English
- Keywords:
- Pubs id:
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1129876
- Local pid:
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pubs:1129876
- Deposit date:
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2021-01-13
- ARK identifier:
Terms of use
- Copyright date:
- 2020
- Rights statement:
- This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
- Licence:
- CC Public Domain Dedication (CC0)
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