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Journal article

Membrane insertion of a voltage sensor helix.

Abstract:

Most membrane proteins contain a transmembrane (TM) domain made up of a bundle of lipid-bilayer-spanning α-helices. TM α-helices are generally composed of a core of largely hydrophobic amino acids, with basic and aromatic amino acids at each end of the helix forming interactions with the lipid headgroups and water. In contrast, the S4 helix of ion channel voltage sensor (VS) domains contains four or five basic (largely arginine) side chains along its length and yet adopts a TM orientation as ...

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Publication status:
Published

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Publisher copy:
10.1016/j.bpj.2010.12.3682

Authors


Chetwynd, A More by this author
Sansom, MS More by this author
Journal:
Biophysical journal
Volume:
100
Issue:
2
Pages:
410-419
Publication date:
2011-01-05
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
URN:
uuid:467f4edd-69f5-4b93-9cfa-ff3f1c3dbbde
Source identifiers:
115915
Local pid:
pubs:115915

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