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Cardiovascular toxicity and distribution kinetics of intravenous chloroquine.

Abstract:

Chloroquine diphosphate (3 mg base kg-1) was given by constant rate intravenous injection over 10 min to 12 healthy adult male volunteers. Plasma concentrations of chloroquine and the principal metabolite desethylchloroquine, electrocardiograph intervals, and arterial blood pressure were measured at frequent intervals to determine the relationship between cardiovascular effects and plasma concentrations. Peak plasma concentrations ranged between 784 and 6649 (mean 2913) ng ml-1. The decline i...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
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Journal:
British journal of clinical pharmacology
Volume:
22
Issue:
1
Pages:
31-36
Publication date:
1986-07-01
DOI:
EISSN:
1365-2125
ISSN:
0306-5251
Source identifiers:
42548
Language:
English
Keywords:
Pubs id:
pubs:42548
UUID:
uuid:465fabdb-d862-44c7-9612-7bb2ead2980c
Local pid:
pubs:42548
Deposit date:
2012-12-19

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