Journal article
Cardiovascular toxicity and distribution kinetics of intravenous chloroquine.
- Abstract:
-
Chloroquine diphosphate (3 mg base kg-1) was given by constant rate intravenous injection over 10 min to 12 healthy adult male volunteers. Plasma concentrations of chloroquine and the principal metabolite desethylchloroquine, electrocardiograph intervals, and arterial blood pressure were measured at frequent intervals to determine the relationship between cardiovascular effects and plasma concentrations. Peak plasma concentrations ranged between 784 and 6649 (mean 2913) ng ml-1. The decline i...
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- Publication status:
- Published
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- Publisher copy:
- 10.1111/j.1365-2125.1986.tb02876.x
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Authors
Bibliographic Details
- Journal:
- British journal of clinical pharmacology
- Volume:
- 22
- Issue:
- 1
- Pages:
- 31-36
- Publication date:
- 1986-07-01
- DOI:
- EISSN:
-
1365-2125
- ISSN:
-
0306-5251
- Source identifiers:
-
42548
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:42548
- UUID:
-
uuid:465fabdb-d862-44c7-9612-7bb2ead2980c
- Local pid:
- pubs:42548
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 1986
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