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Cardiovascular toxicity and distribution kinetics of intravenous chloroquine.

Abstract:

Chloroquine diphosphate (3 mg base kg-1) was given by constant rate intravenous injection over 10 min to 12 healthy adult male volunteers. Plasma concentrations of chloroquine and the principal metabolite desethylchloroquine, electrocardiograph intervals, and arterial blood pressure were measured at frequent intervals to determine the relationship between cardiovascular effects and plasma concentrations. Peak plasma concentrations ranged between 784 and 6649 (mean 2913) ng ml-1. The decline i...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Role:
Author
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Journal:
British journal of clinical pharmacology
Volume:
22
Issue:
1
Pages:
31-36
Publication date:
1986-07-05
DOI:
EISSN:
1365-2125
ISSN:
0306-5251
URN:
uuid:465fabdb-d862-44c7-9612-7bb2ead2980c
Source identifiers:
42548
Local pid:
pubs:42548

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