Journal article : Review
Magic bullets, magic shields, and antimicrobials in between
- Abstract:
- There are only two classes of small-molecule drugs for infectious disease: pathogen-directed antimicrobials and host-directed immunomodulators. The former includes antibiotics and antivirals while the latter comprises corticosteroids such as dexamethasone. Here I inaugurate a third class, immunomodulatory antimicrobials (IAs), which considers small-molecule drugs harbouring both pathogen-directed and host-directed pharmacology. I review seven types of IAs, and argue that their high repositionability and network pharmacological ability to counter multiple pathogen types render them more applicable to pandemic-preparedness research than antivirals.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.0MB, Terms of use)
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- Publisher copy:
- 10.1016/j.pscia.2022.100002
Authors
- Publisher:
- Elsevier BV
- Journal:
- Pharmaceutical science advances More from this journal
- Volume:
- 1
- Issue:
- 1
- Pages:
- 100002
- Publication date:
- 2022-12-13
- DOI:
- ISSN:
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2773-2169
- Pmid:
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41551435
- Language:
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English
- Keywords:
- Subtype:
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Review
- Pubs id:
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2374501
- UUID:
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uuid_4636fe0e-8152-4e25-bd2e-3ee82dfedfc8
- Local pid:
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pubs:2374501
- Source identifiers:
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3696328
- Deposit date:
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2026-01-27
- ARK identifier:
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Terms of use
- Copyright date:
- 2022
- Licence:
- CC Attribution (CC BY)
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