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Cerebral malaria: mechanisms of brain injury and strategies for improved neurocognitive outcome.

Abstract:

Cerebral malaria is the most severe neurological complication of infection with Plasmodium falciparum. With >575,000 cases annually, children in sub-Saharan Africa are the most affected. Surviving patients have an increased risk of neurological and cognitive deficits, behavioral difficulties, and epilepsy making cerebral malaria a leading cause of childhood neurodisability in the region. The pathogenesis of neurocognitive sequelae is poorly understood: coma develops through multiple mechan...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Role:
Author
Journal:
Pediatric research
Volume:
68
Issue:
4
Pages:
267-274
Publication date:
2010-10-05
DOI:
EISSN:
1530-0447
ISSN:
0031-3998
URN:
uuid:461b265c-cc55-48c1-ad24-583765e17c14
Source identifiers:
65265
Local pid:
pubs:65265

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