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FtsK translocation on DNA stops at XerCD-dif.

Abstract:

Escherichia coli FtsK is a powerful, fast, double-stranded DNA translocase, which can strip proteins from DNA. FtsK acts in the late stages of chromosome segregation by facilitating sister chromosome unlinking at the division septum. KOPS-guided DNA translocation directs FtsK towards dif, located within the replication terminus region, ter, where FtsK activates XerCD site-specific recombination. Here we show that FtsK translocation stops specifically at XerCD-dif, thereby preventing removal o...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gkp843

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic acids research Journal website
Volume:
38
Issue:
1
Pages:
72-81
Publication date:
2010-01-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:461b09ca-3d78-4c68-a99c-5dec5c5d568a
Source identifiers:
100242
Local pid:
pubs:100242

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