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Tumour-derived alkaline phosphatase regulates tumour growth, epithelial plasticity and disease-free survival in metastatic prostate cancer

Abstract:

BACKGROUND: Recent evidence suggests that bone-related parameters are the main prognostic factors for overall survival in advanced prostate cancer (PCa), with elevated circulating levels of alkaline phosphatase (ALP) thought to reflect the dysregulated bone formation accompanying distant metastases. We have identified that PCa cells express ALPL, the gene that encodes for tissue nonspecific ALP, and hypothesised that tumour-derived ALPL may contribute to disease progression. METHODS: Function...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/bjc.2016.402

Authors


Snaith, AE More by this author
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Grant:
FP7 Marie Curie Initial Training Network PRO-NEST (grant number 238278)
Publisher:
Cancer Research UK Publisher's website
Journal:
British Journal of Cancer Journal website
Volume:
116
Issue:
2
Pages:
227–236
Publication date:
2016-12-22
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
Pubs id:
pubs:667158
URN:
uri:45dcd7d3-5ae0-4393-9153-d2f611566efc
UUID:
uuid:45dcd7d3-5ae0-4393-9153-d2f611566efc
Local pid:
pubs:667158

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