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Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates.

Abstract:

The p34cdc2 protein kinase is a conserved regulator of the eukaryotic cell cycle. Here we show that residues Thr14 and Tyr15 of mouse p34cdc2 become phosphorylated as mouse fibroblasts proceed through the cell cycle. We have mutated these residues and measured protein kinase activity of the p34cdc2 variants in a Xenopus egg extract. Phosphorylation of residues 14 and 15, which lie within the presumptive ATP-binding region of p34cdc2, normally restrains the protein kinase until it is specifica...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
The EMBO journal
Volume:
10
Issue:
11
Pages:
3321-3329
Publication date:
1991-11-05
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:4594bf23-583c-4a4c-8894-8e1a9875ce2b
Source identifiers:
7393
Local pid:
pubs:7393

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