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Development of GoSlo-SR-5-69, a potent activator of large conductance Ca2+-activated K+ (BK) channels.

Abstract:

We have designed, synthesised and characterised the effects of a number of novel anthraquinone derivatives and assessed their effects on large conductance, Ca(2+) activated K(+) (BK) channels recorded from rabbit bladder smooth muscle cells using the excised, inside/out configuration of the patch clamp technique. These compounds are members of the GoSlo-SR family of compounds, which potently open BK channels and shift the voltage required for half maximal activation (V1/2) negatively. The eff...

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Publication status:
Published

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Journal:
European journal of medicinal chemistry
Volume:
75
Pages:
426-437
Publication date:
2014-03-05
DOI:
EISSN:
1768-3254
ISSN:
0223-5234
URN:
uuid:4590c100-50e3-4c34-b3fc-7d75e893ffd1
Source identifiers:
451160
Local pid:
pubs:451160

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