Journal article
LFA-1 in T cell priming, differentiation, and effector functions
- Abstract:
- The integrin LFA-1 is crucial for T cell entry into mammalian lymph nodes and tissues, and for promoting interactions with antigen-presenting cells. However, it is increasingly evident that LFA-1 plays additional key roles beyond the mere support of adhesion between T cells, the endothelium, and/or antigen-presenting cells. These include roles in homotypic T cell: T cell communication, the induction of intracellular complement activity underlying Th1 effector cell polarization, and the support of long-lasting T cell memory. Here, we summarize briefly current knowledge of LFA-1 biology, discuss novel cytoskeletal regulators of LFA-1 functions, and review new aspects of LFA-1 mechanobiology that are relevant to its function in immunological synapses and in specific pathologies arising from LFA-1 dysregulation.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
-
(Preview, Accepted manuscript, pdf, 343.0KB, Terms of use)
-
- Publisher copy:
- 10.1016/j.it.2021.06.004
Authors
- Publisher:
- Cell Press
- Journal:
- Trends in Immunology More from this journal
- Volume:
- 42
- Issue:
- 8
- Pages:
- 706-722
- Publication date:
- 2021-07-12
- Acceptance date:
- 2021-06-14
- DOI:
- EISSN:
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1471-4981
- ISSN:
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1471-4906
- Language:
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English
- Keywords:
- Pubs id:
-
1185357
- Local pid:
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pubs:1185357
- Deposit date:
-
2021-07-07
- ARK identifier:
Terms of use
- Copyright holder:
- Elsevier
- Copyright date:
- 2021
- Rights statement:
- © 2021 Published by Elsevier Ltd.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Cell Press at: https://doi.org/10.1016/j.it.2021.06.004
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