Neurohumoral and ambulatory haemodynamic adaptations following isometric exercise training in unmedicated hypertensive patients

Taylor, K; Wiles, J; Coleman, D; Leeson, P; Sharma, R; O'Driscoll, J

Journal article

Neurohumoral and ambulatory haemodynamic adaptations following isometric exercise training in unmedicated hypertensive patients

Abstract:: OBJECTIVE:Hypertension remains the leading modifiable risk factor for cardiovascular disease. Isometric exercise training (IET) has been shown to be a useful nonpharmacological intervention for reducing resting blood pressure (BP). This study aimed to measure alterations in office BP, ambulatory BP, cardiac autonomic modulation and inflammatory and vascular biomarkers following a programme of IET in unmedicated hypertensive patients. METHODS:Twenty-four unmedicated stage 1 hypertensive patients (age 43.8 ± 7.3 years; height, 178.1 ± 7 cm; weight 89.7 ± 12.8 kg) were randomly assigned in a cross-over study design, to 4-weeks of home-based IET and control period, separated by a 3-week washout period. Office and ambulatory BP, cardiac autonomic modulation, and inflammatory and vascular biomarkers were recorded pre and post-IET and control periods. RESULTS:Clinic and 24-h ambulatory BP significantly reduced following IET by 12.4/6.2 and 11.8/5.6 mmHg in SBP/DBP, respectively (P < 0.001 for both), compared with the control. The BP adaptations were associated with a significant (P = 0.018) reduction in the average real variability of 24-h ambulatory BP following IET, compared with control. Cardiac autonomic modulation improved by 11% (P < 0.001), baroreceptor reflex sensitivity improved by 47% (P < 0.001), and IL-6 and asymmetric dimethylarginine reduced by 10% (P = 0.022) and 19% (P = 0.023), respectively, which differed significantly to the control period. CONCLUSION:This is the first evidence of durable BP reduction and wider cardiovascular disease risk benefits of IET in a relevant patient population. Our findings support the role of IET as a safe and viable therapeutic and preventive intervention in the treatment of hypertension.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Taylor, K., Wiles, J., Coleman, D., Leeson, P., Sharma, R., & O'Driscoll, J. (2019). Neurohumoral and ambulatory haemodynamic adaptations following isometric exercise training in unmedicated hypertensive patients. Journal of Hypertension, 37(4), 827–836.

MLA Style

Taylor, K, et al. “Neurohumoral and Ambulatory Haemodynamic Adaptations Following Isometric Exercise Training in Unmedicated Hypertensive Patients.” Journal of Hypertension, vol. 37, no. 4, 2019, pp. 827–36.

Chicago Style

Taylor, K, J Wiles, D Coleman, P Leeson, R Sharma, and J O'Driscoll. 2019. “Neurohumoral and Ambulatory Haemodynamic Adaptations Following Isometric Exercise Training in Unmedicated Hypertensive Patients.” Journal of Hypertension 37 (4): 827–36.
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