Desmopressin for prevention of bleeding for thrombocytopenic, critically ill patients undergoing invasive procedures: A randomised, double‐blind, placebo‐controlled feasibility trial

Journal article

Thrombocytopenic patients have an increased risk of bleeding when undergoing invasive procedures. In a multicentre, phase II, blinded, randomised, controlled feasibility trial, critically ill patients with platelet count 100 × 109/L or less were randomised 1:1 to intravenous desmopressin (0.3 µg/kg) or placebo before an invasive procedure. Forty‐three participants (18.8% of those eligible) were recruited, with 41 eligible for analysis. Post‐procedure bleeding occurred in one of 22 (4.5%) in t...

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Authors: Desborough, MJR; Laing, E; Kounali, D; Mora, A; Hodge, R

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Wiley Open Access
• Journal: eJHaem
• Publication date: 2024-06-16
• Acceptance date: 2024-05-13
• DOI: 10.1002/jha2.955
• ISSN: 2688-6146
• Language: English
• Keywords: desmopressin; bleeding disorders; thrombocytopenia