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Exploring mammalian chromatin architecture and its impact on gene regulation

Abstract:

Mammalian chromatin architecture appears hierarchically organised and is composed of chromosome territories, compartments, topologically associating domains (TADs), loops and nucleosomes. The study of chromatin architecture has recently become prevalent due to the advancement of chromosome conformation capture (3C) and microscopy-based techniques. Many studies have predicted that TADs display important functional characteristics such as forming tissue and species-invariant regulatory domai...

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Division:
MSD
Department:
NDM
Role:
Author

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Big Data Institute
Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
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Name:
Medical Research Council
Funder identifier:
http://dx.doi.org/10.13039/501100000265
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2023-03-02

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