Prognostic factors and outcome for children after second central nervous system relapse of acute lymphoblastic leukaemia.

Journal article

The Medical Research Council acute lymphoblastic leukaemia trials (UKALL X and XI) recruited 3,702 children with ALL between January 1985 and March 1997. Seventy-nine children had central nervous system (CNS) involvement in their first two relapses. Fourteen children survived at a median follow-up of 22 months from second relapse; seven (9%) in third remission, two in later remissions and five with disease. Factors predictive of survival from second relapse were site (isolated CNS was better than combined CNS, P = 0.02) and time from diagnosis to second CNS relapse (longer time was better, P = 0.004). Prognosis after second CNS relapse is extremely poor, and palliative therapy is appropriate.

Authors: Morris, E; Harrison, G; Bailey, C; Hann, I; Hill, F

• Publication status: Published
• Journal: British journal of haematology
• Volume: 120
• Issue: 5
• Pages: 787-789
• Publication date: 2003-03-01
• DOI: 10.1046/j.1365-2141.2003.04158.x
• EISSN: 1365-2141
• ISSN: 0007-1048
• Language: English
• Keywords: Humans; Follow-Up Studies; Survival Analysis; Neoplasm Recurrence, Local; Child; Clinical Trials as Topic; Infant; Infant, Newborn; Prognosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Medical Research Council Childhood Leukaemia Working Party; Child, Preschool; Female; Male; Central Nervous System Neoplasms