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Multi-dataset electron density analysis methods for X-ray crystallography

Abstract:

X-ray crystallography is extensively deployed to determine the structure of proteins, both unbound and bound to different molecules. Crystallography has the power to visually reveal the binding of small molecules, assisting in their development in structure-based lead design. Currently, however, the methods used to detect binding, and the subjectivity of inexperienced modellers, are a weak-point in the field.

Existing methods for ligand identification are fundamentally flawed when i...

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Department:
University of Oxford
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University of Oxford
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Department:
University of Oxford
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UCB Pharma
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UCB Pharma
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Grant:
EP/G037280/1
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Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
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