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Immunogenicity of the tuberculosis vaccine MVA85A is reduced by coadministration with EPI vaccines in a randomized controlled trial in Gambian infants.

Abstract:

New tuberculosis vaccines are urgently needed to curtail the current epidemic. MVA85A is a subunit vaccine that could enhance immunity from BCG vaccination. To determine MVA85A safety and immunogenicity as well as interactions with other routine vaccines administered in infancy, we randomized healthy 4-month-old infants who had received Bacille Calmette-Guérin at birth to receive Expanded Program on Immunization (EPI) vaccines alone, EPI and MVA85A simultaneously, or MVA85A alone. Adverse eve...

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Authors


Odutola, AA More by this author
Owiafe, PK More by this author
Owolabi, OA More by this author
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Journal:
Science translational medicine
Volume:
3
Issue:
88
Pages:
88ra56
Publication date:
2011-06-05
DOI:
EISSN:
1946-6242
ISSN:
1946-6234
URN:
uuid:44ebb2fe-9fe8-42b1-8bde-d115c1c18c9f
Source identifiers:
176648
Local pid:
pubs:176648

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