The Cid1 poly(U) polymerase.

Journal article

The Schizosaccharomyces pombe cytoplasmic protein Cid1 acts as a poly(U) polymerase (PUP). Polyadenylated actin mRNA, a target of this activity, is uridylated upon arrest in S phase and is likely to be one of many such Cid1 targets. This RNA uridylation pathway appears to be conserved, as Cid1 orthologs in Arabidopsis thaliana, Caenorhabditis elegans and humans display PUP activity either in vitro or in Xenopus laevis oocytes. Here, we review the literature on Cid1, other PUPs and uridylation, a conserved and previously under-appreciated mechanism of RNA regulation.

Authors: Rissland, O; Norbury, C

• Publication status: Published
• Journal: Biochimica et biophysica acta
• Volume: 1779
• Issue: 4
• Pages: 286-294
• Publication date: 2008-04-01
• DOI: 10.1016/j.bbagrm.2008.03.003
• ISSN: 0006-3002
• Language: English
• Keywords: RNA, Fungal; Poly U; Animals; Xenopus laevis; Caenorhabditis elegans Proteins; Caenorhabditis elegans; Xenopus Proteins; S Phase; Schizosaccharomyces pombe Proteins; Schizosaccharomyces; Actins; Arabidopsis; RNA, Plant; Sequence Homology, Amino Acid; RNA, Helminth; Nucleotidyltransferases; Cell Cycle Proteins; Arabidopsis Proteins