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Hypoxia-inducible expression of tumor-associated carbonic anhydrases.

Abstract:

The transcriptional complex hypoxia-inducible factor-1 (HIF-1) has emerged as an important mediator of gene expression patterns in tumors, although the range of responding genes is still incompletely defined. Here we show that the tumor-associated carbonic anhydrases (CAs) are tightly regulated by this system. Both CA9 and CA12 were strongly induced by hypoxia in a range of tumor cell lines. In renal carcinoma cells that are defective for the von Hippel-Lindau (VHL) tumor suppressor, up-regul...

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Publication status:
Published

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Authors


Wykoff, CC More by this author
Beasley, NJ More by this author
Watson, PH More by this author
Turner, KJ More by this author
Pastorek, J More by this author
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Journal:
Cancer research
Volume:
60
Issue:
24
Pages:
7075-7083
Publication date:
2000-12-05
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:44cce837-8d4e-42b2-91f2-ce66b1ce2153
Source identifiers:
11845
Local pid:
pubs:11845

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