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Structural studies on human 2-oxoglutarate dependent oxygenases.

Abstract:

2-Oxoglutarate and ferrous iron-dependent oxygenases have emerged as an important family of human enzymes that catalyse hydroxylations and related demethylation reactions. Their substrates in humans include proteins, nucleic acids, lipids and small molecules. They play roles in collagen biosynthesis, hypoxic sensing, regulation of gene expression and lipid biosynthesis/metabolism. Structural analyses, principally employing crystallography, have revealed that all of these oxygenases possess a ...

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Publication status:
Published

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Publisher copy:
10.1016/j.sbi.2010.08.006

Authors

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Current opinion in structural biology More from this journal
Volume:
20
Issue:
6
Pages:
659-672
Publication date:
2010-12-01
DOI:
EISSN:
1879-033X
ISSN:
0959-440X
Language:
English
Keywords:
Pubs id:
pubs:83834
UUID:
uuid:44b745a2-abad-4cb5-8c9d-448360e61567
Local pid:
pubs:83834
Source identifiers:
83834
Deposit date:
2012-12-19

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