- Abstract:
-
CBP (CREB (cAMP responsive element binding protein) binding protein (CREBBP)) and P300 (adenovirus E1A-associated 300 kDa protein) are two closely related histone acetyltransferases (HATs) that play a key role in the regulation of gene transcription. Both proteins contain a bromodomain flanking the HAT catalytic domain that is important for the targeting of CBP/P300 to chromatin and which offeres an opportunity for the development of protein-protein interaction inhibitors. Here we present the...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Publisher copy:
- 10.1021/acs.jmedchem.6b00774
-
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- Publisher:
- American Chemical Society Publisher's website
- Journal:
- Journal of Medicinal Chemistry Journal website
- Volume:
- 59
- Issue:
- 19
- Pages:
- 8889–8912
- Publication date:
- 2016-09-27
- DOI:
- EISSN:
-
1520-4804
- ISSN:
-
0022-2623
- Pubs id:
-
pubs:648035
- URN:
-
uri:44a065f6-7c68-4647-a989-220a9780b8b0
- UUID:
-
uuid:44a065f6-7c68-4647-a989-220a9780b8b0
- Local pid:
- pubs:648035
- Paper number:
- 19
- Language:
- English
- Keywords:
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 American Chemical Society.
Journal article
Development of selective CBP/P300 benzoxazepine bromodomain inhibitors
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