Journal article
Deep sequencing of B cell receptor repertoires from COVID-19 patients reveals strong convergent immune signatures
- Abstract:
- Deep sequencing of B cell receptor (BCR) heavy chains from a cohort of 31 COVID-19 patients from the UK reveals a stereotypical naive immune response to SARS-CoV-2 which is consistent across patients. Clonal expansion of the B cell population is also observed and may be the result of memory bystander effects. There was a strong convergent sequence signature across patients, and we identified 1,254 clonotypes convergent between at least four of the COVID-19 patients, but not present in healthy controls or individuals following seasonal influenza vaccination. A subset of the convergent clonotypes were homologous to known SARS and SARS-CoV-2 spike protein neutralizing antibodies. Convergence was also demonstrated across wide geographies by comparison of data sets between patients from UK, USA, and China, further validating the disease association and consistency of the stereotypical immune response even at the sequence level. These convergent clonotypes provide a resource to identify potential therapeutic and prophylactic antibodies and demonstrate the potential of BCR profiling as a tool to help understand patient responses.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 2.7MB, Terms of use)
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- Publisher copy:
- 10.3389/fimmu.2020.605170
Authors
- Publisher:
- Frontiers Media
- Journal:
- Frontiers in Immunology More from this journal
- Volume:
- 11
- Article number:
- 605170
- Publication date:
- 2020-12-15
- Acceptance date:
- 2020-11-16
- DOI:
- EISSN:
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1664-3224
- Pmid:
-
33384691
- Language:
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English
- Keywords:
- Pubs id:
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1151863
- Local pid:
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pubs:1151863
- Deposit date:
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2021-03-16
Terms of use
- Copyright holder:
- JD Galson et al.
- Copyright date:
- 2020
- Rights statement:
- © 2020 Galson, Schaetzle, Bashford-Rogers, Raybould, Kovaltsuk, Kilpatrick, Minter, Finch, Dias, James, Thomas, Lee, Betley, Cavlan, Leech, Deane, Seoane, Caldas, Pennington, Pfeffer and Osbourn. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Licence:
- CC Attribution (CC BY)
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