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Different degrees of somatotroph ablation compromise pituitary growth hormone cell network structure and other pituitary endocrine cell types.

Abstract:

We have generated transgenic mice with somatotroph-specific expression of a modified influenza virus ion channel, (H37A)M2, leading to ablation of GH cells with three levels of severity, dependent on transgene copy number. GH-M2(low) mice grow normally and have normal-size pituitaries but 40-50% reduction in pituitary GH content in adult animals. GH-M2(med) mice have male-specific transient growth retardation and a reduction in pituitary GH content by 75% at 42 d and 97% by 100 d. GH-M2(high)...

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Publication status:
Published

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Publisher copy:
10.1210/en.2009-0539

Authors


Carmignac, D More by this author
Chauvet, N More by this author
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Journal:
Endocrinology
Volume:
151
Issue:
1
Pages:
234-243
Publication date:
2010-01-05
DOI:
EISSN:
1945-7170
ISSN:
0013-7227
URN:
uuid:4495ea8d-6ade-4e43-8825-db44a7c5cdbb
Source identifiers:
311989
Local pid:
pubs:311989

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