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Model-based Bayesian inference of neural activity and connectivity from all-optical interrogation of a neural circuit

Abstract:

Population activity measurement by calcium imaging can be combined with cellular resolution optogenetic activity perturbations to enable the mapping of neural connectivity in vivo. This requires accurate inference of perturbed and unperturbed neural activity from calcium imaging measurements, which are noisy and indirect, and can also be contaminated by photostimulation artifacts. We have developed a new fully Bayesian approach to jointly inferring spiking activity and neural connectivity fro...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
ORCID:
0000-0001-5884-794X
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Publisher:
Curran Associates Publisher's website
Volume:
30
Pages:
3487-3497
Publication date:
2017-09-04
Acceptance date:
2017-09-04
ISSN:
1049-5258
Pubs id:
pubs:871184
URN:
uri:4495220c-423f-46d8-9019-c65cf9f82d05
UUID:
uuid:4495220c-423f-46d8-9019-c65cf9f82d05
Local pid:
pubs:871184
ISBN:
978-1-5108-6096-4

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