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Effects of ageing on cortical neural dynamics and local sleep homeostasis in mice

Abstract:

Healthy ageing is associated with marked effects on sleep, including its daily amount and architecture, as well as the specific electroencephalogram (EEG) oscillations. Neither the neurophysiological underpinnings, nor the biological significance of these changes are understood, and crucially the question remains whether ageing is associated with reduced sleep need or a diminished capacity to generate sufficient sleep. Here we tested the hypothesis that ageing may affect local cortical networ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1523/JNEUROSCI.2513-17.2018

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
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Grant:
Industrial CASE grant with Eli Lilly (BB/K011847/1)
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Grant:
Strategic Award (098461/Z/12/Z)
Publisher:
Society for Neuroscience Publisher's website
Journal:
Journal of Neuroscience Journal website
Volume:
38
Issue:
16
Pages:
3911-3928
Publication date:
2018-03-26
Acceptance date:
2018-02-22
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
Pubs id:
pubs:826880
URN:
uri:447a7cf4-6d57-44c5-aa38-dc46a6016b4b
UUID:
uuid:447a7cf4-6d57-44c5-aa38-dc46a6016b4b
Local pid:
pubs:826880

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