Journal article : Review
Host restriction, pathogenesis and chronic carriage of typhoidal Salmonella
- Abstract:
- While conjugate vaccines against typhoid fever have recently been recommended by the World Health Organization for deployment, the lack of a vaccine against paratyphoid, multidrug resistance and chronic carriage all present challenges for the elimination of enteric fever. In the past decade, the development of in vitro and human challenge models has resulted in major advances in our understanding of enteric fever pathogenesis. In this review, we summarise these advances, outlining mechanisms of host restriction, intestinal invasion, interactions with innate immunity and chronic carriage, and discuss how this knowledge may progress future vaccines and antimicrobials.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 3.8MB, Terms of use)
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- Publisher copy:
- 10.1093/femsre/fuab014
Authors
- Publisher:
- Federation of European Microbiological Societies
- Journal:
- FEMS Microbiology Reviews More from this journal
- Volume:
- 45
- Issue:
- 5
- Publication date:
- 2021-03-05
- Acceptance date:
- 2021-03-03
- DOI:
- EISSN:
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1574-6976
- ISSN:
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0168-6445
- Pmid:
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33733659
- Language:
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English
- Keywords:
- Subtype:
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Review
- Pubs id:
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1210899
- Local pid:
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pubs:1210899
- Deposit date:
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2021-12-18
Terms of use
- Copyright holder:
- Barton et al.
- Copyright date:
- 2021
- Rights statement:
- © The Author(s) 2021. Published by Oxford University Press on behalf of FEMS. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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