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Journal article

The DNA sequence and biological annotation of human chromosome 1.

Abstract:

The reference sequence for each human chromosome provides the framework for understanding genome function, variation and evolution. Here we report the finished sequence and biological annotation of human chromosome 1. Chromosome 1 is gene-dense, with 3,141 genes and 991 pseudogenes, and many coding sequences overlap. Rearrangements and mutations of chromosome 1 are prevalent in cancer and many other diseases. Patterns of sequence variation reveal signals of recent selection in specific genes ...

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Publication status:
Published

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Publisher copy:
10.1038/nature04727

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Journal:
Nature
Volume:
441
Issue:
7091
Pages:
315-321
Publication date:
2006-05-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:445daf7b-867a-4f25-8451-d6fa09ab53ff
Source identifiers:
103217
Local pid:
pubs:103217

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