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Drug-resistant genotypes and multi-clonality in Plasmodium falciparum analysed by direct genome sequencing from peripheral blood of malaria patients

Abstract:

Naturally acquired blood-stage infections of the malaria parasite Plasmodium falciparum typically harbour multiple haploid clones. The apparent number of clones observed in any single infection depends on the diversity of the polymorphic markers used for the analysis, and the relative abundance of rare clones, which frequently fail to be detected among PCR products derived from numerically dominant clones. However, minority clones are of clinical interest as they may harbour genes conferring ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0023204

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Institution:
University of Oxford
Role:
Author
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Foundation for Innovative New Diagnostics More from this funder
UCL Hospitals Comprehensive Biomedical Research Centre for Infection More from this funder
United Kingdom Health Protection Agency More from this funder
Wellcome Trust More from this funder
MRC Centre for Genomics and Global Health More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Volume:
6
Issue:
8
Pages:
Article: e23204
Publication date:
2011-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:444cd13e-d409-417e-886d-0f8a6c0d0a8d
Source identifiers:
172054
Local pid:
pubs:172054

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