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A method for generating single metalloprotein crystals in well-defined redox states: combined electrochemical control and infrared microspectroscopic imaging of a NiFe hydrogenase crystal

Abstract:
We describe an approach to generating and verifying well-defined redox states in metalloprotein single crystals by combining electrochemical control with synchtroton infrared microspectroscopic imaging. For NiFe hydrogenase 1 from Escherichia coli we demonstrate fully reversible and uniform electrochemical reduction from the oxidised inactive to the fully reduced state, and temporally resolve steps during this reduction.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1039/C7CC02591B

Authors

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Inorganic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Inorganic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Inorganic Chemistry
Role:
Author


More from this funder
Funding agency for:
Carr, S
Evans, R
Armstrong, F
Vincent, K
Grant:
BB/L009722/1
BB/N006321/1
BB/N006321/1
BB/L009722/1
BB/L009722/1
BB/N006321/1
EP/N013514/1
More from this funder
Funding agency for:
Ash, P
Reeve, H
Rowbotham, J
Vincent, K
Grant:
EP/N013514/1
EP/N013514/1
EP/N013514/1
EP/N013514/1


Publisher:
Royal Society of Chemistry
Journal:
Chemical Communications More from this journal
Volume:
53
Issue:
43
Pages:
5858-5861
Publication date:
2017-05-09
Acceptance date:
2017-05-09
DOI:
EISSN:
1364-548X
ISSN:
1359-7345


Pubs id:
pubs:693888
UUID:
uuid:4449384c-d6db-4d9c-ad90-78a12bd1d23b
Local pid:
pubs:693888
Source identifiers:
693888
Deposit date:
2017-05-09
ARK identifier:

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