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Journal article

Evaluation of metal-mediated DNA binding of benzoxazole ligands by electrospray ionization mass spectrometry.

Abstract:

The binding of a series of benzoxazole analogs with different amide- and ester-linked side chains to duplex DNA in the absence and presence of divalent metal cations is examined. All ligands were found to form complexes with Ni2+, Cu2+, and Zn2+, with 2:1 ligand/metal cation binding stoichiometries dominating for ligands containing shorter side chains (2, 6, 7, and 8), while 1:1 complexes were the most abundant for ligands with long side chains (9, 10, and 11). Ligand binding with duplex DNA ...

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Publication status:
Published

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Publisher copy:
10.1016/j.jasms.2007.05.009

Authors


Mazzitelli, CL More by this author
Rodriguez, M More by this author
Kerwin, SM More by this author
Brodbelt, JS More by this author
Journal:
Journal of the American Society for Mass Spectrometry
Volume:
19
Issue:
2
Pages:
209-218
Publication date:
2008-02-05
DOI:
EISSN:
1879-1123
ISSN:
1044-0305
URN:
uuid:44410f80-9c84-47de-9ed8-9acb466e575a
Source identifiers:
182140
Local pid:
pubs:182140

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