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Harnessing the power of invariant natural killer T cells in cancer immunotherapy

Abstract:

Invariant natural killer T (iNKT) cells are a distinct subset of innate-like lymphocytes bearing an invariant T-cell receptor, through which they recognize lipid antigens presented by monomorphic CD1d molecules. Upon activation, iNKT cells are capable of not only having a direct effector function but also transactivating NK cells, maturing dendritic cells, and activating B cells, through secretion of several cytokines and cognate TCR-CD1d interaction. Endowed with the ability to orchestrate a...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3389/fimmu.2017.01829

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM - Investigative Medicine Division
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM - Investigative Medicine Division
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Grant:
MRC Human Immunology Unit
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Grant:
Program Grant #C399/A2291)
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Grant:
Biomedical Research Centre, Oxford
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
8
Issue:
DEC
Pages:
Article: 1829
Publication date:
2017-12-18
Acceptance date:
2017-12-04
DOI:
ISSN:
1664-3224
Pubs id:
pubs:813498
URN:
uri:443deb98-106c-4b5a-92e1-7aadcd9610c1
UUID:
uuid:443deb98-106c-4b5a-92e1-7aadcd9610c1
Local pid:
pubs:813498

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