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Stable and unstable malaria hotspots in longitudinal cohort studies in Kenya

Abstract:

Background: Infectious diseases often demonstrate heterogeneity of transmission among host populations. This heterogeneity reduces the efficacy of control strategies, but also implies that focusing control strategies on "hotspots" of transmission could be highly effective. Methods and findings: In order to identify hotspots of malaria transmission, we analysed longitudinal data on febrile malaria episodes, asymptomatic parasitaemia, and antibody titres over 12 y from 256 homesteads in three s...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pmed.1000304

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Institution:
"Kilifi KEMRI- Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research - Coast, Kilifi, Kenya", "University of Oxford"
Department:
Medical Sciences Division - Clinical Vaccinology and Tropical Medicine,Centre for (CCVTM)
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Institution:
"Kilifi KEMRI- Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research - Coast, Kilifi, Kenya", "University of Oxford"
Department:
Medical Sciences Division - Clinical Vaccinology and Tropical Medicine,Centre for (CCVTM)
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Institution:
Karolinska Instututet, Stockholm, Sweden
Department:
Department of Medicine Solna
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Institution:
"University of Oxford", "Centre for Geographic Medicine Research - Coast, Kenya Medical Research Institute/Wellcome Trust Research Programme, Nairobi, Kenya"
Department:
Malaria Public Health & Epidemiology Group
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Institution:
Kilifi KEMRI- Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research - Coast, Kilifi, Kenya
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Funding agency for:
Philip Bejon
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Funding agency for:
Thomas N. Williams
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Funding agency for:
Faith H. A. Osier
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Funding agency for:
Simon I. Hay
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Funding agency for:
Kevin Marsh
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Medicine Journal website
Volume:
7
Issue:
7
Pages:
Article: e1000304
Publication date:
2010-07-05
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
URN:
uuid:43ff9034-5504-446c-96f3-cdf813444bb3
Local pid:
ora:4115
Language:
English
Keywords:
Subjects:

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