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Selective estrogen receptor modulator inhibits osteocyte apoptosis during abrupt estrogen withdrawal: implications for bone quality maintenance.

Abstract:

Estrogens exert positive effects on the quantity and quality of bone, including the maintenance of osteocytes through the inhibition of their apoptosis. Ideally, selective estrogen receptor modulators (SERMs) confer all of the positive bone-associated effects of estrogens without any adverse effects. In a similar way to estrogen, the raloxifene analog LY 117018 has been shown to prevent bone loss in ovariectomized (OVX) rats. In this study, we investigated whether the osteocyte-sparing effect...

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Publication status:
Published

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Publisher copy:
10.1007/s00223-007-9049-6

Authors


Collishaw, S More by this author
Mosley, JR More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Calcified tissue international
Volume:
81
Issue:
2
Pages:
139-144
Publication date:
2007-08-05
DOI:
EISSN:
1432-0827
ISSN:
0171-967X
URN:
uuid:43cc06ad-c2f4-47bf-9ea5-015796dd50e7
Source identifiers:
473467
Local pid:
pubs:473467

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