Journal article icon

Journal article

Cryo-electron microscopy structures and progress toward a dynamic understanding of KATP channels

Abstract:

Adenosine triphosphate (ATP)-sensitive K+ (KATP) channels are molecular sensors of cell metabolism. These hetero-octameric channels, comprising four inward rectifier K+ channel subunits (Kir6.1 or Kir6.2) and four sulfonylurea receptor (SUR1 or SUR2A/B) subunits, detect metabolic changes via three classes of intracellular adenine nucleotide (ATP/ADP) binding site. One site, located on the Kir subunit, causes inhibition of the channel when ATP or ADP is bound. The other two sites, located on t...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1085/jgp.201711978

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Divison
Department:
Physiology Anatomy and Genetics
Oxford college:
St Hughs College
ORCID:
0000-0002-9335-0936
Publisher:
Rockefeller University Press Publisher's website
Journal:
Journal of General Physiology Journal website
Volume:
150
Issue:
5
Pages:
653-669
Publication date:
2018-04-23
Acceptance date:
2018-03-26
DOI:
EISSN:
1540-7748
ISSN:
0022-1295
Pubs id:
pubs:846085
URN:
uri:43a5ec39-2ad0-4401-86c0-698a2a981727
UUID:
uuid:43a5ec39-2ad0-4401-86c0-698a2a981727
Local pid:
pubs:846085
Language:
English

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP